abstract：:Bacillus subtilis has a bifurcated respiratory chain composed of a cytochrome branch and a quinol oxidase branch. The respiratory complexes of this bacterium have been elucidated mostly by the analysis of the genome and by the isolation of individual complexes. The supramolecular organization of this respiratory chain...

journal_title：Journal of bioenergetics and biomembranes

authors： García Montes de Oca LY,Chagolla-López A,González de la Vara L,Cabellos-Avelar T,Gómez-Lojero C,Gutiérrez Cirlos EB

更新日期：2012-08-01 00:00:00

abstract：:Hydroxyl radical (HO•) production in photosystem II (PSII) was studied by electron paramagnetic resonance (EPR) spin-trapping technique. It is demonstrated here that the exposure of PSII membranes to heat stress (40 °C) results in HO• formation, as monitored by the formation of EMPO-OH adduct EPR signal. The presence ...

journal_title：Journal of bioenergetics and biomembranes

authors： Yadav DK,Pospíšil P

更新日期：2012-06-01 00:00:00

abstract：:Available data indicate that minocycline, an antibiotic of the tetracycline family, has cytoprotective properties due to a direct interaction with mitochondria. Yet, the data in the case of isolated mitochondria suggest discrepant or even detrimental effect(s) of the interaction. We have studied the cytoprotective act...

journal_title：Journal of bioenergetics and biomembranes

authors： Karachitos A,Jordan J,Kmita H

更新日期：2012-06-01 00:00:00

abstract：:The 95 kDa subunit a of eukaryotic V-ATPases consists of a C-terminal, ion-translocating part and an N-terminal cytosolic domain. The latter's N-terminal domain (~40 kDa) is described to bind in an acidification-dependent manner with cytohesin-2 (ARNO), giving the V-ATPase the putative function as pH-sensing receptor....

journal_title：Journal of bioenergetics and biomembranes

authors： Dip PV,Saw WG,Roessle M,Marshansky V,Grüber G

更新日期：2012-06-01 00:00:00

abstract：:2-Arachidonoylglicerol (2-AG) is an endocannabinoid that mimics the pharmacological effects of Δ⁹ tetrahydrocannabinol, the psychoactive component of the plant Cannabis sativa. It is present in many mammalian tissues, such as brain, liver, spleen, heart and kidney, where it exerts different biological effects either r...

journal_title：Journal of bioenergetics and biomembranes

authors： Zaccagnino P,D'Oria S,Romano LL,Di Venere A,Sardanelli AM,Lorusso M

更新日期：2012-04-01 00:00:00

abstract：:Recent advances in structural biology underlying mechanisms of channel gating have strengthened our knowledge about how K(+) channels can be inter-convertible between conductive and non-conductive states. We have reviewed and combined mutagenesis with biochemical, biophysical and structural information in order to und...

journal_title：Journal of bioenergetics and biomembranes

authors： Raja M,Olrichs NK,Vales E,Schrempf H

更新日期：2012-02-01 00:00:00

abstract：:The small alkylating molecule, 3-bromopyruvate (3BP), is a potent and specific anticancer agent. 3BP is different in its action from most currently available chemo-drugs. Thus, 3BP targets cancer cells' energy metabolism, both its high glycolysis ("Warburg Effect") and mitochondrial oxidative phosphorylation. This inh...

journal_title：Journal of bioenergetics and biomembranes

authors： Ko YH,Verhoeven HA,Lee MJ,Corbin DJ,Vogl TJ,Pedersen PL

更新日期：2012-02-01 00:00:00

abstract：:Although the "Warburg effect", i.e., elevated glucose metabolism to lactic acid (glycolysis) even in the presence of oxygen, has been recognized as the most common biochemical phenotype of cancer for over 80 years, its biochemical and genetic basis remained unknown for over 50 years. Work focused on elucidating the un...

journal_title：Journal of bioenergetics and biomembranes

authors： Pedersen PL

更新日期：2012-02-01 00:00:00

abstract：:In this study we used tightly-coupled mitochondria from Yarrowia lipolytica and Dipodascus (Endomyces) magnusii yeasts. The two yeast strains are good alternatives to Saccharomyces cerevisiae, being aerobes containing well structured mitochondria (thus ensuring less structural limitation to observe their appreciable s...

journal_title：Journal of bioenergetics and biomembranes

authors： Trendeleva T,Sukhanova E,Ural'skaya L,Saris NE,Zvyagilskaya R

更新日期：2011-12-01 00:00:00

abstract：:Escherichia coli has four [NiFe]-hydrogenases (Hyd); three of these, Hyd-1, Hyd-2 and Hyd-3 have been characterized well. In this study the requirement for the F(0)F(1)-ATP synthase for the activities of the hydrogen-oxidizing hydrogenases Hyd-1 and Hyd-2 was examined. During fermentative growth on glucose at pH 7.5 a...

journal_title：Journal of bioenergetics and biomembranes

authors： Trchounian K,Pinske C,Sawers RG,Trchounian A

更新日期：2011-12-01 00:00:00

abstract：:We studied the importance of respiratory fitness in S. cerevisiae lifespan, response to caloric restriction (CR) and mtDNA stability. Mutants harboring mtDNA instability and electron transport defects do not respond to CR, while tricarboxylic acid cycle mutants presented extended lifespans due to CR. Interestingly, mt...

journal_title：Journal of bioenergetics and biomembranes

authors： Tahara EB,Cezário K,Souza-Pinto NC,Barros MH,Kowaltowski AJ

更新日期：2011-10-01 00:00:00

abstract：:Calorie restriction (CR) has been shown to decrease H(2)O(2) production in liver mitochondria, although it is not known if this is due to uniform changes in all mitochondria or changes in particular mitochondrial sub-populations. To address this issue, liver mitochondria from control and CR mice were fractionated usin...

journal_title：Journal of bioenergetics and biomembranes

authors： Hagopian K,Chen Y,Simmons Domer K,Soo Hoo R,Bentley T,McDonald RB,Ramsey JJ

更新日期：2011-06-01 00:00:00

abstract：:In the mitochondrial F(O)F(1) ATP-synthase/ATPase complex, subunits α and β are part of the extrinsic portion that catalyses ATP synthesis. Since there are no reports about genes and proteins from these subunits in crustaceans, we analyzed the cDNA sequences of both subunits in the whiteleg shrimp Litopenaeus vannamei...

journal_title：Journal of bioenergetics and biomembranes

authors： Martinez-Cruz O,Garcia-Carreño F,Robles-Romo A,Varela-Romero A,Muhlia-Almazan A

更新日期：2011-04-01 00:00:00

abstract：:Methylmalonic acidemia is one of the most prevalent inherited metabolic disorders involving neurological deficits. In vitro experiments, animal model studies and tissue analyses from human patients suggest extensive impairment of mitochondrial energy metabolism in this disease. This review summarizes changes in mitoch...

journal_title：Journal of bioenergetics and biomembranes

authors： Melo DR,Kowaltowski AJ,Wajner M,Castilho RF

更新日期：2011-02-01 00:00:00

abstract：:Epilepsy is a neurological disorder characterized by spontaneous, recurrent and paroxysmal cerebral discharge, clinically leading to persistent alterations in function and morphology of neurons. Oxidative stress is one of possible mechanisms in the pathogenesis of epilepsy. Oxidative stress resulting from mitochondria...

journal_title：Journal of bioenergetics and biomembranes

authors： Chang SJ,Yu BC

更新日期：2010-12-01 00:00:00

abstract：:Dysfunction of neuronal metabolism is central to all forms of seizure activity. Clinical, genetic and metabolic studies have implicated mitochondria in the process. Alterations in electron transport, generation of reactive oxygen species, calcium metabolism and apoptosis all have been described in human and animal ner...

journal_title：Journal of bioenergetics and biomembranes

authors： Sack GH Jr

更新日期：2010-12-01 00:00:00

abstract：:Epilepsy is considered one of the most common neurological disorders worldwide. The burst firing neurons associated with prolonged epileptic discharges could lead to a large number of changes with events of cascades at the cellular level. From its role as the cellular powerhouse, mitochondria also play a crucial role ...

journal_title：Journal of bioenergetics and biomembranes

authors： Chen SD,Chang AY,Chuang YC

更新日期：2010-12-01 00:00:00

abstract：:Huntington's disease (HD) is an inheritable neurological disorder coursing with degeneration of basal ganglia and producing chorea and dementia. One common factor accounting for neurodegeneration in this disorder is mitochondrial deterioration at both morphologic and functional levels. The development of experimental ...

journal_title：Journal of bioenergetics and biomembranes

authors： Pérez-De la Cruz V,Carrillo-Mora P,Santamaría A

更新日期：2010-06-01 00:00:00

abstract：:Uncoupling proteins (UCPs) located in the inner mitochondrial membrane are involved in the regulation of energy balance. Thus far, 5 UCP isoforms have been identified, but controversies exist in the research focused on the function of the UCPs (except UCP1) in the pathogenesis of obesity. Because of the known cross-re...

journal_title：Journal of bioenergetics and biomembranes

authors： Zhang CM,Zhang M,Zhu JG,Ji CB,Zhu C,Kou CZ,Qin DN,Tong ML,Guo XR

更新日期：2010-06-01 00:00:00

abstract：:Little is known on antimicrobial peptide permeation through outer membrane channels in gram-negative bacteria. Herein, we probed at a single-molecule level the interaction of two different peptides, magainin 2 and HPA3P with OmpF from E. coli. HPA3P is an analogue of the antimicrobial peptide HP(2-20) isolated from th...

journal_title：Journal of bioenergetics and biomembranes

authors： Apetrei A,Asandei A,Park Y,Hahm KS,Winterhalter M,Luchian T

更新日期：2010-04-01 00:00:00

abstract：:Maturation of c-type cytochromes involves the covalent and stereospecific enzymatic attachment of a heme b via thioether linkages to two conserved cysteines within apocytochromes. Horse cytochrome c is readily matured into its native holoform in the cytoplasm of E. coli when co-expressed with yeast cytochrome c heme l...

journal_title：Journal of bioenergetics and biomembranes

authors： Tenger K,Khoroshyy P,Rákhely G,Zimányi L

更新日期：2010-04-01 00:00:00

abstract：:Incubation of T. cruzi epimastigotes with the lectin Cramoll 1,4 in Ca(2+) containing medium led to agglutination and inhibition of cell proliferation. The lectin (50 microg/ml) induced plasma membrane permeabilization followed by Ca(2+) influx and mitochondrial Ca(2+) accumulation, a result that resembles the classic...

journal_title：Journal of bioenergetics and biomembranes

authors： Fernandes MP,Inada NM,Chiaratti MR,Araújo FF,Meirelles FV,Correia MT,Coelho LC,Alves MJ,Gadelha FR,Vercesi AE

更新日期：2010-02-01 00:00:00

abstract：:Mitochondrial impairment has been collecting more and more attention as a contributing factor to the etiology of Parkinson's disease. Above all, the NADH-quinone oxidoreductase, complex I, of the respiratory chain seems to be most culpable. Complex I dysfunction is translated to an increased production of reactive oxy...

journal_title：Journal of bioenergetics and biomembranes

authors： Marella M,Seo BB,Yagi T,Matsuno-Yagi A

更新日期：2009-12-01 00:00:00

abstract：:Conformational changes within the subunit b-dimer of the E. coli ATP synthase occur upon binding to the F(1) sector. ESR spectra of spin-labeled b at room temperature indicated a pivotal point in the b-structure at residue 62. Spectra of frozen b +/- F(1) and calculated interspin distances suggested that where contact...

journal_title：Journal of bioenergetics and biomembranes

authors： Zaida TM,Hornung T,Volkov OA,Hoffman AD,Pandey SJ,Wise JG,Vogel PD

更新日期：2008-12-01 00:00:00

abstract：:We have previously shown that vacuolar H+-ATPase subcomplex V(o) from mung bean contains subunit d, however, its sequence and function were unknown. In the present study, we report the cloning and recombinant over expression of subunit d from mung bean in E. coli. To study the function of subunit d, two vacuolar H+-AT...

journal_title：Journal of bioenergetics and biomembranes

authors： Ouyang Z,Li Z,Zhang X

更新日期：2008-12-01 00:00:00

abstract：:The advantages of using bacterial systems to study the mechanism and function of cytochrome bc (1) complexes do not extend readily to their structural investigations. High quality crystals of bacterial complexes have been difficult to obtain despite the enzymes' smaller sizes and simpler subunit compositions compared ...

journal_title：Journal of bioenergetics and biomembranes

authors： Xia D,Esser L,Elberry M,Zhou F,Yu L,Yu CA

更新日期：2008-10-01 00:00:00

abstract：:The organization of the oxidative phosphorylation (OXPHOS) system within the inner mitochondrial membrane appears to be far more complicated than previously thought. In particular, the individual protein complexes of the OXPHOS system (complexes I to V) were found to specifically interact forming defined supramolecula...

journal_title：Journal of bioenergetics and biomembranes

authors： Dudkina NV,Sunderhaus S,Boekema EJ,Braun HP

更新日期：2008-10-01 00:00:00

abstract：:The multi-subunit vacuolar-type H(+)-ATPase consists of a V(1) domain (A-H subunits) catalyzing ATP hydrolysis and a V(0) domain (a, c, c', c", d, e) responsible for H(+) translocation. The mammalian V(0) d subunit is one of the least-well characterized, and its function and position within the pump are still unclear....

journal_title：Journal of bioenergetics and biomembranes

authors： Smith AN,Francis RW,Sorrell SL,Karet FE

更新日期：2008-08-01 00:00:00

abstract：:Eukaryotic porins or VDACs are a class of transmembrane proteins mainly localized in the outer mitochondrial membrane, whose function is to allow the diffusion of metabolites between the cytosol and the mitochondrion. In Drosophila melanogaster, as in other organisms, a small family of genes encoding porins has been d...

journal_title：Journal of bioenergetics and biomembranes

authors： Specchia V,Guarino F,Messina A,Bozzetti MP,De Pinto V

更新日期：2008-06-01 00:00:00

abstract：:The total amount of cellular mitochondrial DNA (mtDNA) varies widely and seems to be related to the nature and metabolic state of tissues and cells in culture. It is not known, however, whether this variation has any significance in vivo, and to which extent it regulates energy production. To better understand the imp...

journal_title：Journal of bioenergetics and biomembranes

authors： Rocher C,Taanman JW,Pierron D,Faustin B,Benard G,Rossignol R,Malgat M,Pedespan L,Letellier T

更新日期：2008-04-01 00:00:00

abstract：:Idebenone (IDE), a synthetic analog of coenzyme Q, strongly activates glycerol phosphate (GP) oxidation in brown adipose tissue mitochondria. GP oxidase, GP cytochrome c oxidoreductase and GP dehydrogenase activities were all significantly stimulated by 13 muM IDE. Substituted derivatives of IDE acetyl- and methoxyide...

journal_title：Journal of bioenergetics and biomembranes

authors： Rauchová H,Drahota Z,Bergamini C,Fato R,Lenaz G

更新日期：2008-04-01 00:00:00

abstract：:ATP binding cassette (ABC) transporters comprise an extended protein family involved in the transport of a broad spectrum of solutes across membranes. They consist of a common architecture including two ATP-binding domains converting chemical energy into conformational changes and two transmembrane domains facilitatin...

journal_title：Journal of bioenergetics and biomembranes

authors： Nikles D,Tampé R

更新日期：2007-12-01 00:00:00

abstract：:By manipulating the physical properties of oxygen, cells are able to harvest the large thermodynamic potential of oxidation to provide a substantial fraction of the energy necessary for cellular processes. The enzyme largely responsible for this oxygen manipulation is cytochrome c oxidase, which resides at the inner m...

journal_title：Journal of bioenergetics and biomembranes

authors： Herrmann PC,Herrmann EC

更新日期：2007-06-01 00:00:00

abstract：:ATP1-111, a suppressor of the slow-growth phenotype of yme1Delta lacking mitochondrial DNA is due to the substitution of phenylalanine for valine at position 111 of the alpha-subunit of mitochondrial ATP synthase (Atp1p in yeast). The suppressing activity of ATP1-111 requires intact beta (Atp2p) and gamma (Atp3p) subu...

journal_title：Journal of bioenergetics and biomembranes

authors： Francis BR,White KH,Thorsness PE

更新日期：2007-04-01 00:00:00

abstract：:There has been increased interest in the use of naturally occurring compounds with chemopreventive and chemotherapeutic effects in the treatment of cancers. This review summarizes the most recent advances that provide new insights into the molecular mechanisms underlying the apoptotic potential of nutritional suppleme...

journal_title：Journal of bioenergetics and biomembranes

authors： Kwon KB,Park BH,Ryu DG

更新日期：2007-02-01 00:00:00

abstract：:Many previous investigations have consistently reported that caloric restriction (40%), which increases maximum longevity, decreases mitochondrial reactive species (ROS) generation and oxidative damage to mitochondrial DNA (mtDNA) in laboratory rodents. These decreases take place in rat liver after only seven weeks of...

journal_title：Journal of bioenergetics and biomembranes

authors： Sanz A,Gómez J,Caro P,Barja G

更新日期：2006-12-01 00:00:00

abstract：:The Nm23-H1/nucleoside diphosphate (NDP) kinase A is a metastasis suppressor, besides its enzymatic activity. The mutant S120G has been found in high-grade neuroblastomas. The mutant protein, once denatured in urea, is unable to refold in vitro. A size-exclusion chromatography analysis of the folding/association pathw...

journal_title：Journal of bioenergetics and biomembranes

authors： Lascu I

更新日期：2006-08-01 00:00:00

abstract：:Vicious cycle theories of aging and oxidative stress propose that ROS produced by the mitochondrial electron transport chain damage the mitochondria leading exponentially to more ROS production and mitochondrial damage. Although this theory is widely discussed in the field of research on aging and oxidative stress, th...

journal_title：Journal of bioenergetics and biomembranes

authors： Sanz A,Caro P,Gómez J,Barja G

更新日期：2006-04-01 00:00:00

abstract：:We report on the influence of dielectric pulse injection on the energy metabolism of yeast cells with a planar interdigitated electrode interface. The energy metabolism was measured via NADH fluorescence. The application of dielectric pulses results in a distinct decrease of the fluorescence, indicating a response of ...

journal_title：Journal of bioenergetics and biomembranes

authors： Reiher A,Warnke C,Radoch S,Witte H,Krtschil A,Mair T,Müller SC,Krost A

更新日期：2006-04-01 00:00:00

abstract：:Mitochondrial reactive oxygen species (ROS) production was investigated in mitochondria extracted from liver of rats treated with or without metformin, a mild inhibitor of respiratory chain complex 1 used in type 2 diabetes. A high rate of ROS production, fully suppressed by rotenone, was evidenced in non-phosphorylat...

journal_title：Journal of bioenergetics and biomembranes

authors： Batandier C,Guigas B,Detaille D,El-Mir MY,Fontaine E,Rigoulet M,Leverve XM

更新日期：2006-02-01 00:00:00